最 簡單 檢測 出 「阿茲海默症 」的 方式 ：血液 檢測 A Simple Blood Test to Detect Alzheimer's |洪 姮 娥 Herng Er Horng | TEDxTaipei most|simple|test|to detect|Alzheimer's disease|possessive particle|method|blood|test|A|simple|blood|test|to|detect|Alzheimer's|Horng|Er|Horng|Herng|Er|Horng|TEDxTaipei Um exame de sangue simples para detectar Alzheimer | Herng Er Horng | TEDxTaipei A Simple Blood Test to Detect Alzheimer's | Herng Er Horng | TEDxTaipei

大家 好 everyone|hello Hello everyone 其實 我 不太好 actually|I|am not very well Actually, I'm not doing very well

（笑聲 ） laughter (Laughter)

因為 我 今天 要 介紹 一個 非常 傷腦筋 的 問題 because|I|today|want to|introduce|a|very|troublesome|(possessive particle)|question Because today I want to introduce a very troublesome issue.

就是 阿茲海默症 （AD） that is|Alzheimer's disease|(AD) That is Alzheimer's disease (AD).

這個 問題 呢 this|question|question particle This issue is very serious,

非常 嚴重 ，因為 全世界 的 發病率 很 高 very|serious|because|the whole world|possessive particle|incidence rate|very|high because the incidence rate is very high worldwide.

65 歲 以上 的 人 ，20 個 人 裡面 是 有 一 個 會 是 患者 years|above|possessive particle|people|measure word|people|among|is|have|one|measure word|will|be|patient Among people aged 65 and older, 1 in 20 will be a patient.

然後 呢 ，85 歲 以上 的 甚至於 4 個 裡面 就 有 一個 then|question particle|years|above|possessive particle|even|measure word|inside|already|has|one And for those aged 85 and older, it's even 1 in 4.

所以 在 老年化 的 社會 裡面 當然 是 我們 非常 嚴重 的 問題 so|in|aging|possessive particle|society|inside|of course|is|we|very|serious|possessive particle|problem So in an aging society, this is certainly a very serious issue for us.

每個 家庭 都 面臨 到 AD 的 威脅 every|family|all|faces|to|Alzheimer's disease|possessive particle|threat Every family is facing the threat of Alzheimer's disease.

因為 我 跟 很多 朋友 談過 because|I|with|many|friends|have talked Because I have talked to many friends.

他們 或多或少 都 有 一些 長輩 都 ...... 目前 還是 長輩 They all have some elders, more or less... and they are still elders.

但是 有 年齡層 往 下降 的 趨勢 but|has|age group|towards|decline|possessive particle|trend However, there is a trend of the age group declining.

長輩 都 或多或少 會 有 這個 問題 elders|all|more or less|will|have|this|problem Elders will more or less have this problem.

那 我們 要 探究 它 的 原因 then|we|will|investigate|it|possessive particle|reason Then we need to explore its causes.

因為 你 知道 它 的 原因 以後 大約 對 這個 病 的 了解 會 比較 知道 because|you|know|it|possessive particle|reason|in the future|approximately|regarding|this|illness|possessive particle|understanding|will|relatively|know Because once you know its causes, you will have a better understanding of this disease.

也 知道 怎麼 來 處理 also|know|how|to|handle You will also know how to deal with it.

然後 呢 ，基本上 它 是 腦神經 細胞 受到 傷害 then|question particle|basically|it|is|brain nerve|cell|received|damage Basically, it is the brain nerve cells that are damaged.

那 我們 腦神經 細胞 ，一般來講 我們 頭腦 裡面 有 腦神經 細胞 then|we|brain nerve|cells|generally speaking|we|brain|inside|have|brain nerve|cells So we have brain nerve cells, generally speaking, we have brain nerve cells in our heads.

腦神經 細胞 我們 有 神經纖維 來 做 傳導 的 作用 brain nerve|cells|we|have|nerve fibers|to|perform|conduction|possessive particle|function Brain nerve cells have nerve fibers that serve the function of conduction.

那 神經纖維 呢 ，它 的 ...... that|nerve fiber|question particle|it|possessive particle As for the nerve fibers, they...

每條 神經纖維 為 什麼 不 打結 each|nerve fiber|for|what|not|knotting Why doesn't each nerve fiber get tangled?

是 因為 它 有 一個 叫 Tau 蛋白 大家 看到 一個 Tau ， Tau 蛋白 is|because|it|has|a|called|Tau|protein|everyone|sees|a|Tau|Tau|protein It is because it has a protein called Tau. Everyone sees a Tau, Tau protein.

是 讓 它 不要 打結 is|let|it|not|tangle It prevents it from tangling.

如果 發病 的話 那 Tau 蛋白 會 脫落 if|onset of disease|then|then|Tau|protein|will|detach If it gets sick, then the Tau protein will fall off.

那 神經纖維 就 會 打結 that|nerve fibers|then|will|tangle Then the nerve fibers will tangle.

另外 有 一個 原因 就是說 你 有 發病 的 時候 additionally|has|one|reason|that is|you|have|illness|possessive particle|time Additionally, there is another reason that when you are ill,

頭腦 裡面 身體 的 酵素 brain|inside|body|possessive particle|enzyme the enzymes in your body,

會 把 有 一個 叫做 Aβ 的 蛋白質 will|particle indicating action|have|a|called|Aβ|possessive particle|protein will chop a protein called Aβ,

把 它 砍成 細片 to cut|it|into|small pieces into small pieces.

那 砍成 細段 了 以後 呢 that|cut into|small pieces|past tense marker|after|question particle After being cut into small pieces,

它會 沉積 ， 沉積 在 腦神經 上面 it will accumulate, accumulating on the brain nerves.

這 兩個 原因 these|two|reasons These two reasons,

一個 是 Tau 蛋白 脫落 one|is|Tau|protein|detachment one is the detachment of Tau protein.

一個 是 Aβ 被 砍成 細段 以後 沉積 變成 斑塊 one|is|Aβ|by|cut into|small segments|after|deposition|becomes|plaques One is that Aβ is cut into small segments and then accumulates to form plaques.

那 這樣的話 都 會 造成 腦細胞 死亡 then|in that case|all|will|cause|brain cells|death In this case, it will cause the death of brain cells.

那 我們 看一看 腦細胞 死亡 的 一個 過程 then|we|take a look at|brain cells|death|possessive particle|one|process Now let's take a look at the process of brain cell death.

第一個 ，它 會 從 海馬 迴 開始 hippocampus first|it|will|from|hippocampus|circuit|start| First, it starts from the hippocampus.

海馬 迴 開始 的 時候 它 會 造成 什麼樣 ？ hippocampus|circuit|start|possessive particle|when|it|will|cause|what kind What happens when the hippocampus starts?

因為 海馬 迴 是 在 主掌 我們 because|hippocampus|circuit|is|in|controlling|us Because the hippocampus is in charge of our

一個 人 的 記憶 跟 認知 a|person|possessive particle|memory|and|cognition memory and cognition.

所以 你 會 開始 就 覺得 so|you|will|start|then|feel So you will start to feel.

好像 記憶 會 常常 忘東 忘西 seems|memory|will|often|forget things|forget other things It seems that memory often forgets things here and there.

但是 忘東 忘西 不要 緊張 but|forget east|forget west|don't|nervous But forgetting things here and there is nothing to worry about.

忘東 忘西 不 一定 就是 阿茲海默症 forgetting east|forgetting west|not|necessarily|just|Alzheimer's disease Forgetting things here and there does not necessarily mean Alzheimer's disease.

（笑聲 ） laughter (Laughter)

然後 呢 ，還有 就是說 then|question particle|also|that is to say Then, there is also the saying

它 的 認知 會 有 異常 it|possessive particle|cognition|will|have|abnormalities Its cognition will have abnormalities

會 有 異常 人際 的 溝通 will|have|abnormal|interpersonal|possessive particle|communication There will be abnormal interpersonal communication

但是 ，從 海馬 迴 它 會 慢慢 發展 到 全腦 but|from|hippocampus|circuit|it|will|slowly|develop|to|whole brain However, from the hippocampus, it will slowly develop to the whole brain

嚴重 的 時候 serious|possessive particle|time In severe cases.

而且 ，這 一個 發展 的 早期 中晚期 ，到 嚴重 期 moreover|this|one|development|possessive particle|early|mid-late stage|to|severe|period Moreover, during the early to late stages of this development, it reaches a severe stage.

這個 基本上 是 不 能夠 回頭 的 this|basically|is|not|able to|turn back|(particle indicating past action) This basically cannot be reversed.

為 什麼 呢 ？ why|what|question particle Why is that?

因為 腦細胞 死亡 ，沒有 那麼 容易 because|brain cells|die|not|that|easy Because brain cells die, it's not that easy.

甚至 有人 說 不能 治 even|someone|said|cannot|cure Some even say it cannot be cured.

有人 說會 增生 ，但是 portion 也 就是 部分 不會 太 大 someone|said will|increase|but|portion|also|is|part|will not|too|large Some say there will be regeneration, but the portion will not be too large.

那 如果 是 嚴重 期 呢 ，會 怎麼樣 呢 ？ then|if|is|severe|period|question particle|will|how|question particle So what happens if it is a severe stage?

你 可以 看到 腦死 you|can|see|brain death You can see brain death.

因為 腦細胞 死亡 會 使得 腦 非常 嚴重 萎縮 because|brain cells|death|will|cause|brain|very|severe|atrophy Because the death of brain cells will cause the brain to shrink severely.

這個 健康 腦 跟 嚴重 的 腦的 區別 大家 可以 看得 非常 清楚 this|healthy|brain|and|serious|possessive particle|brain's|distinction|everyone|can|see|very|clearly The difference between a healthy brain and a severely damaged brain is very clear to everyone.

然後 呢 ，是不是 那麼 可怕 ？ then|question particle|is it not|that|scary So, is it really that scary?

從今 天 我 健康 明天 我 就 變 阿茲海默症 了 ？ from now|day|I|healthy|tomorrow|I|then|become|Alzheimer's disease|past tense marker From today I am healthy, tomorrow will I have Alzheimer's disease?

我 想 ，幸運 的 是 沒有 那麼 嚴重 I|think|lucky|possessive particle|is|not have|that|serious I think, fortunately, it is not that serious.

大家 可以 看到 它 中間 還有 一個 everyone|can|see|it|in the middle|still has|one Everyone can see that there is still a stage in the middle.

叫做 「輕度 認知障礙 」的 那個 階段 called|mild|cognitive impairment|possessive particle|that|stage It's called 'mild cognitive impairment'.

這個 障礙 呢 ，你 如果 開始 有 辦法 把 它 診斷 出來 this|obstacle|question particle|you|if|start|have|method|particle indicating disposal|it|diagnose|out This obstacle, if you start to find a way to diagnose it,

它 其實 有 差不多 6 年 的 時間 it|actually|has|about|years|possessive particle|time it actually has been around for almost 6 years.

如果 不 處理 ，它 有 80% 的 人 if|not|handled|it|has|possessive particle|people If not addressed, 80% of people

會 走向 阿茲海默症 的 一個 途徑 will|lead to|Alzheimer's disease|possessive particle|one|pathway will head towards a path of Alzheimer's disease.

那 所以 呢 ，在 這個 階段 是 非常 重要 的 ，特別 要 講 then|so|question particle|at|this|stage|is|very|important|possessive particle|especially|must|speak So, at this stage, it is very important, especially to mention.

因為 這個 階段 呢 ，很 長 because|this|stage|question particle|very|long Because this stage is quite long.

而且 這個 階段 呢 是 基本上 醫生 還 可以 處理 and|this|stage|question particle|is|basically|doctor|still|can|handle And at this stage, basically, doctors can still handle it.

那個 就是 我們 把 它 叫做 早期 MCI 的 階段 that|is|we|(a preposition indicating the action of taking)|it|called|early|MCI|(possessive particle)|stage We call this the early MCI stage.

M 就是 輕度 的 is|just|mild|particle indicating possession or description M is mild.

C 就是 認知 的 is|just|cognition|possessive particle C is cognitive.

I 就是 障礙 I|just|obstacle I is impairment.

所以 MCI 的 階段 呢 如果 能夠 提早 檢驗 出來 so|MCI|possessive particle|stage|question particle|if|can|early|testing|out So if the stage of MCI can be detected early.

其實 可以 藉由 在 醫生 的 指導 之下 actually|can|by|in|doctor|possessive particle|guidance|under In fact, it can be done under the guidance of a doctor.

可以 藉由 運動 、營養 認知 訓練 、藥物 can|through|exercise|nutrition|cognitive|training|medication It can be achieved through exercise, nutritional cognitive training, and medication.

那 藥物 呢 ，現成 已經 有 藥物 了 that|medicine|question particle|ready|already|has|medicine|past action marker As for the medication, there are already available drugs.

那 我們 知道 嘛 醫藥 的 發展 ，藥 的 發展 then|we|know|question particle|medicine|possessive particle|development|drug|possessive particle|development We know that the development of medicine and drugs is ongoing.

基本上 是 從 開始 可能 有 的 藥效 不是 那麼 好 basically|is|from|the beginning|may|have|(possessive particle)|efficacy|not|that|good Basically, the initial effects of the medication may not be that good.

慢慢 慢慢 大家 又 研發 更好 的 藥 出來 slowly|slowly|everyone|again|develop|better|possessive particle|medicine|out Slowly, everyone has developed better medications.

所以 事實上 現在 是 有藥 的 來治 那個 MCI 的 這個 階段 so|in fact|now|is|there is medication|possessive particle|to treat|that|MCI|possessive particle|this|stage So in fact, there are now medications available to treat the MCI stage.

但是 問題 是 ：在 醫學 上 有沒有 辦法 去 把 MCI 檢驗 出來 ？ but|question|is|in|medicine|field|is there|method|to|(particle indicating action on an object)|MCI|test|out But the question is: is there a way in medicine to detect MCI?

很多 人 到 醫院 去 的 時候 其實 都 是 回天乏力 了 many|people|arrive|hospital|go|past action particle|when|actually|all|are|exhausted|past tense marker Many people actually go to the hospital when they are already exhausted.

因為 都 已經 受到 損害 了 because|all|already|received|damage|past tense marker Because they have already been harmed.

那 如果 我們 能夠 then|if|we|are able to If we can,

在 還沒 有 受到 損害 的 時候 能夠 把 它 檢驗 出來 at|not yet|have|received|damage|possessive particle|time|able to|particle indicating disposal|it|test|out detect it before any harm has been done.

這是 非常 重要 的 問題 this is|very|important|possessive particle|question This is a very important question.

它 診斷 的 方法 基本上 現在 我們 可以 把 它 分為 it|diagnosis|possessive particle|method|basically|now|we|can|particle indicating disposal|it|divide into The methods of diagnosis can basically be divided into.

問卷 ——這個 傳統 方法 到 現在 還在 用 questionnaire|this|traditional|method|until|now|still|used Questionnaires - this traditional method is still in use today.

醫學影像 ——比較 進步 了 以後 是 醫學影像 medical imaging|compared to|progress|past tense marker|in the future|is|medical imaging Medical imaging - has progressed significantly and is now medical imaging.

但是 ，目前 在 全世界 大家 都 在衝 這個 分子 檢驗 這 一塊 but|currently|in|the whole world|everyone|all|is rushing|this|molecular|testing|this|area However, currently everyone around the world is rushing into this molecular testing area.

這 一塊 呢 ，是 比較 科學 的 this|piece|question particle|is|relatively|scientific|particle indicating possession or modification This area is more scientific.

更 科學 的 、更 客觀 的 more|scientific|(possessive particle)|more|objective|(possessive particle) More scientific, more objective.

然後 呢 ，你 可以 看 ，問卷 3 小時 then|question particle|you|can|read|questionnaire|hours And then, you can see, the questionnaire takes 3 hours.

然後 正子 造影 ，就是 影像 ，3 小時 then|positron|imaging|that is|image|hours Then the positron emission tomography, which is the imaging, takes 3 hours.

然後 ，分子 檢驗 目前 大家 是 在 抽 脊髓 液 then|molecule|test|currently|everyone|is|in|drawing|spinal|fluid Next, the molecular testing is currently being done by drawing spinal fluid.

脊髓 液 的話 要 6 小時 spinal cord|fluid|if|takes|hours For spinal fluid, it takes 6 hours.

所以 我們 一個個 來看 so|we|one by one|will look at So let's look at them one by one.

問卷 是 非常 主觀 的 questionnaire|is|very|subjective|possessive particle The questionnaire is very subjective.

當 你家 人 有 一些 徵象 的 時候 when|your family|people|have|some|symptoms|possessive particle|time When your family members have some symptoms,

是 會 帶到 醫生 那邊 去 用 的 是 臨床 失智 評量 表 is|will|take|doctor|over there|to|used|possessive particle|is|clinical|dementia|assessment|scale it will be taken to the doctor using the clinical dementia assessment scale.

那 這個 跟 患者 被問 的 時候 他 的 情緒 有關 that|this|with|patient|being asked|possessive particle|when|he|possessive particle|emotion|related to This is related to the patient's emotions when they are being asked.

然後 跟 醫生 的 主觀 判斷 也 有關 then|with|doctor|possessive particle|subjective|judgment|also|related Then it also relates to the subjective judgment of the doctor.

所以 它 只能 診斷出 正常 跟 中度 以上 的 失智 患者 so|it|can only|diagnose|normal|and|moderate|above|(possessive particle)|dementia|patients So it can only diagnose normal and moderate to severe dementia patients.

中度 以上 ，那 要 記住 那個 已經 是 回天乏術 了 moderate|above|that|should|remember|that|already|is|beyond help|past tense marker Moderate to severe, which means that it is already beyond help.

那 在 這個 的 時候 呢 ，可疑 then|at|this|possessive particle|time|question particle|suspicious At this time, it is suspicious.

就是說 在 很 輕度 ，我們 剛剛 提 的 MCI 階段 ，要 怎麼辦 ？ that is to say|in|very|mild|we|just now|mentioned|possessive particle|MCI|stage|should|what to do That is to say, in very mild cases, what should we do at the MCI stage we just mentioned?

它 檢驗 不 出來 ，用 問卷 檢驗 不 出來 it|test|not|come out|using|questionnaire|test|not|come out It cannot be detected; it cannot be detected using questionnaires.

然後 呢 ，我們 說 ，難道 這個 只能 用 主觀 的方法 嗎 ？ then|question particle|we|said|could it be that|this|can only|use|subjective|method|question particle Then, we ask, can this only be assessed using subjective methods?

那 這樣 對 大家 的 健康 then|this way|for|everyone|possessive particle|health So, what does this mean for everyone's health?

是 非常悲哀 的 一件 事 is|very sad|possessive particle|one|thing It is a very sad thing.

那 醫學影像 呢 ，這 大 儀器 ，很 貴 that|medical imaging|question particle|this|large|instrument|very|expensive As for the medical imaging, this large instrument is very expensive.

那 它 得到 的 是 什麼 ？ that|it|received|possessive particle|is|what So what does it obtain?

斑塊 影像 還有 腦部 萎縮 的 情況 plaque|imaging|and also|brain|atrophy|possessive particle|condition Plaque images and the condition of brain atrophy.

這個 階段 ，剛剛 我們 有 介紹 過 那個 阿茲海默症 發病 的 原因 this|stage|just|we|have|introduced|past tense marker|that|Alzheimer's disease|onset|possessive particle|cause At this stage, we just introduced the causes of Alzheimer's disease.

大家 知道 這 已經 來不及 了 everyone|knows|this|already|too late|past tense marker Everyone knows it's already too late.

所以 我們 期盼 的 早期 診斷 so|we|hope|possessive particle|early|diagnosis So the early diagnosis we hope for.

也 是 沒有 辦法 also|is|no|solution Is also not possible.

到 這個 階段 用 這個 昂貴 的 醫學影像 to|this|stage|use|this|expensive|possessive particle|medical imaging At this stage, using this expensive medical imaging

不 一定 貴 的 就 好 not|necessarily|expensive|(possessive particle)|then|good Not everything expensive is good

人家 說 藥 不 一定 貴 的 是 好 others|say|medicine|not|necessarily|expensive|(possessive particle)|is|good People say that not everything expensive medicine is good

儀器 也 是 一樣 ，不 一定 貴 的 就是 好 instrument|also|is|the same|not|necessarily|expensive|(possessive particle)|just|good The same goes for instruments, not everything expensive is good

那 我們 分子 檢測 是 大家 努力 的 一個 方向 then|we|molecular|testing|is|everyone|effort|possessive particle|one|direction So our molecular testing is a direction that everyone is working hard on.

它 用 的 是 脊髓 液 it|uses|possessive particle|is|spinal|fluid It uses cerebrospinal fluid.

大家 認為 因為腦 跟 脊髓 是 相通 的 Everyone believes that because the brain and spinal cord are connected,

所以 脊髓 液 應該 可以 檢驗 得 出來 so|spinal|fluid|should|be able to|test|obtain|result the cerebrospinal fluid should be able to be tested.

結果 呢 ，不然 result|question particle|otherwise So, what happened is, otherwise.

因為 我們 脊髓 液 的 這些 不 正常 蛋白 含量 非常 高 because|we|spinal|fluid|possessive particle|these|not|normal|protein|levels|very|high Because the levels of these abnormal proteins in our cerebrospinal fluid are very high.

那 有 病 沒 病 ，它 的 差異 不 大 that|has|illness|no|illness|it|possessive particle|difference|not|big Whether there is a disease or not, the difference is not significant.

所以 會 使得 它 檢驗 沒有 辦法 來 區分 正常 或 罹病 的 期數 so|will|cause|it|examination|no|method|to|distinguish|normal|or|diseased|possessive particle|period Therefore, it makes it impossible to distinguish between normal or diseased stages in the examination.

然後 呢 ，它 的 危險度 也 高 then|question particle|it|possessive particle|danger level|also|high Then, its level of danger is also high.

它 要 專業 醫師 ，然後 有 危險度 it|needs|professional|doctor|then|has|level of danger It requires a professional doctor, and it has a level of danger.

然後 醫生 的 快樂 天堂 then|doctor|possessive particle|happiness|paradise Then, the happy paradise of doctors.

醫生 他們 心目 中 的 快樂 天堂 doctor|they|in their mind|in|possessive particle|happiness|paradise The happy paradise in the minds of doctors.

你 看 ，那個 笑得 很 可愛 you|look|that|laughs|very|cute Look, that one is smiling very cutely.

它 的 快樂 天堂 要 抽血 檢查 it|possessive particle|happy|paradise|needs to|blood draw|test Its happy paradise requires a blood test.

抽血 檢查 是 方便 又 輕鬆 有利於 預防 疾病 的 監控 blood draw|test|is|convenient|and|easy|beneficial for|prevention|disease|possessive particle|monitoring Blood tests are convenient and easy, beneficial for monitoring disease prevention.

但是 呢 ，問題 來 了 but|question particle|problem|come|past tense marker However, the problem arises.

我們 血液 中 不 正常 蛋白 的 含量 非常 低 we|blood|in|not|normal|protein|possessive particle|level|very|low The content of abnormal proteins in our blood is very low.

它 差不多 是 脊髓 液 的 千分之一 it|almost|is|spinal|fluid|possessive particle|one thousandth It is almost one thousandth of the spinal fluid.

在 這個 階段 呢 它 是 沒有 儀器 可以 量 出來 的 at|this|stage|question particle|it|is|no|instrument|can|measure|out|particle At this stage, there are no instruments that can measure it.

全世界 沒有 儀器 可以 量 出來 the whole world|does not have|instrument|can|measure|out There are no instruments in the world that can measure it.

雖然 是 大家 都 在 做 分子 檢測 研究 although|is|everyone|all|in|doing|molecular|testing|research Although everyone is conducting molecular testing research.

但是 全世界 是 沒有 儀器 的 However, there are no instruments in the world.

所以 我們 在 做 這個 研究 的 時候 so|we|at|doing|this|research|possessive particle|time So when we are doing this research,

我們 必須 執行 下面 兩個 任務 we|must|execute|the following|two|tasks we must carry out the following two tasks.

第一個 就是 方法 還有 儀器 the first|is|method|and|instrument The first one is the method and the instruments.

第二個 任務 呢 ，就是 說 second|task|question particle|that is to say|to say The second task is to say.

好啊 ，你量 出來 以後 ，這些 跟 病 之間 的 關係 有 什麼 關係 ？ okay|you measure|out|after|these|with|illness|between|possessive particle|relationship|has|what|relationship Okay, after you measure it, what is the relationship between these and the disease?

這 兩個 都 是 非常 大 的 一個 問題 this|two|both|are|very|big|possessive particle|one|question Both of these are very big questions.

都 需要 花掉 我們 非常 多 的 精力 去 做 的 all|need|spend|we|very|much|(possessive particle)|energy|to|do|(past action particle) All of this requires us to spend a lot of energy to do.

所以 我們 跟 台大 醫院 合作 以後 so|we|with|National Taiwan University|hospital|cooperate|in the future So after we collaborated with National Taiwan University Hospital,

我們 就 接受 這 兩個 任務 開始 方法 跟 儀器 we|then|accept|these|two|tasks|start|method|and|instruments we accepted these two tasks to start methods and instruments.

我 是 利用 磁性 奈米 的 一個 磁珠 I|am|using|magnetic|nanometer|possessive particle|a|magnetic bead I am using a magnetic nanoparticle.

然後 去 做 試劑 then|go|do|test Then go make the reagent.

磁珠 掛上 抗體 就 變成 我們 的 試劑 magnetic bead|attaching|antibody|then|becomes|our|possessive particle|reagent The magnetic beads coated with antibodies become our reagent.

我 用 這個 磁性 的 奈米 粒子 去 做 檢驗 I|use|this|magnetic|possessive particle|nano|particle|to|do|test I use these magnetic nanoparticles for testing.

那 磁性 納奈米 粒子 呢 它 在 磁場 轉動 that|magnetic|nanometer|particle|question particle|it|in|magnetic field|rotates The magnetic nanoparticles rotate in a magnetic field.

磁場 可以 交流 磁場 magnetic field|can|interact|magnetic field Magnetic fields can interact with magnetic fields.

會 不會 太 學術 ？我 不知道 不過 交流 磁場 ── will|won't|too|academic|I|don't know|but|communication|magnetic field Isn't that a bit too academic? I don't know, but the interaction of magnetic fields ──

（笑聲 ） laughter (laughter)

──是 可 以 來 轉動 奈米 磁性 粒子 is|can|to|come|rotate|nano|magnetic|particle ── can rotate nano magnetic particles.

因為 你 知道 嘛 ，磁場 轉 because|you|know|question particle|magnetic field|rotates Because you know, the magnetic field rotates.

那個 磁矩 ，一個 一個 磁矩 就 跟著 轉 ，可以 轉動 它 that|magnetic moment|each|one|magnetic moment|then|following|rotating|can|rotate|it That magnetic moment, each magnetic moment rotates along with it, and it can be rotated.

轉動 了 以後 就 有 磁 訊號 rotation|past tense marker|after|then|has|magnetic|signal After it rotates, there will be a magnetic signal.

我們 就量 這個 磁 訊號 we|will measure|this|magnetic|signal We measure this magnetic signal.

我們 心目中 就要 量 這個 磁訊號 we|in our mind|should|measure|this|magnetic signal We need to measure this magnetic signal in our minds.

然後 我們 如果 把 一些 我們 剛剛 的 不 正常 蛋白質 掛上去 以後 then|we|if|to put|some|we|just now|possessive particle|not|normal|protein|put on|after Then, if we attach some of the abnormal proteins we just mentioned.

橘色 的 那個 就 掛上去 以後 orange|possessive particle|that|then|hang up|after The orange one will attach after that.

然後 有 的 就 會 變成 一團 ，然後 變大 then|have|possessive particle|then|will|become|a mass|then|grow larger Then some will turn into a clump and grow larger.

不管 變大 或者 一團 ，大家 可以 看到 它 轉動 的 情形 是 變成 這個 樣子 no matter|get bigger|or|a ball|everyone|can|see|it|rotating|possessive particle|situation|is|becoming|this|shape No matter if it gets bigger or becomes a mass, everyone can see that its rotation changes to this state.

變大 的 轉慢 了 became larger|possessive particle|turned slower|past tense marker The larger one rotates more slowly.

然後 呢 ，一團 的 不動 了 then|question particle|a group|possessive particle|not moving|past tense marker And then, the mass becomes stationary.

所以 整個 磁 訊號 會 降低 so|entire|magnetic|signal|will|decrease So the overall magnetic signal will decrease.

我們 的 實驗 證明 它 是 可以 降低 we|possessive particle|experiment|prove|it|is|can|reduce Our experiment proves that it can be reduced.

降低 了 以後 ，我 用 它 降低 的 量 來 換算 我們 待 測物 lower|past tense marker|afterwards|I|use|it|lowering|possessive particle|amount|to|convert|we|to be|measured object After reducing, I used the amount I reduced to convert the concentration of the substance we are testing.

也就是不正常蛋白質的濃度 that is the concentration of abnormal protein That is, the concentration of abnormal proteins.

用 這個 方法 呢 因為 是 看 減量 ，不是 增量 use|this|method|question particle|because|is|looking at|reduction|not|increase Using this method, because it looks at the reduction, not the increase.

我們 說 越多越好 we|speak|the more the better The more we say, the better.

訊號 越大越 多 ，我們 剛好 相反 signal|the bigger it is the more|more|we|just|opposite The stronger the signal, the more we are just the opposite.

我們 減量 越 多 ，那個 濃度 越高 we|reduce the amount|the more|much|that|concentration|the higher The more we reduce, the higher the concentration.

所以 我們 把 它 命名 這個 命名 是 我們 命名 的 so|we|particle indicating action|it|named|this|naming|is|we|naming|possessive particle So we named it, this naming is what we named.

叫做 「免疫 磁 減量 」的方法 就 簡稱 IMR called|immune|magnetic|reduction|method|then|abbreviated as|IMR The method called "Immune Magnetic Reduction" is abbreviated as IMR.

就像 MRI 一樣 ，我們 叫 它 IMR just like|MRI|same|we|call|it|IMR Just like MRI, we call it IMR.

IMR 現在 全世界 的 阿茲海默 論壇 IMR|now|worldwide|possessive particle|Alzheimer's|forum IMR is now a topic in Alzheimer's forums around the world.

在 網路上 ，阿茲海默 論壇 on|the internet|Alzheimer's|forum On the internet, Alzheimer's forums.

已經 把 我們 的 方法 放進去 了 ，做 比較 already|(particle indicating disposal)|we|possessive particle|method|put in|past tense marker|do|comparison We have already incorporated our methods and made comparisons.

而且 有 非常 高 的 一個 確診 的 效率 and|has|very|high|possessive particle|one|diagnosis|possessive particle|efficiency Moreover, there is a very high confirmation efficiency.

所以 全世界 已經 看到 這個 問題 了 so|the whole world|already|has seen|this|problem|past tense marker So the whole world has already seen this issue.

那 第二個 任務 是 病症 相關性 that|second|task|is|disease|correlation The second task is the correlation of symptoms.

我們 介紹 一下 病症 相關性 we|introduce|briefly|symptoms|correlation Let us introduce the correlation of the disease.

也就是說 它 的 這些 that is to say|it|possessive particle|these In other words, what are these.

不 正常 蛋白質 的 濃度 跟 病症 有 什麼 關係 not|normal|protein|possessive particle|concentration|with|disease|has|what|relationship What is the relationship between the concentration of these abnormal proteins and the disease?

我量 出 濃度 了 ，可以 量 因為 我們 儀器 夠 好 I measured|out|concentration|past tense marker|can|measure|because|we|instrument|sufficiently|good I have measured the concentration, and I can measure it because our instruments are good enough.

然後 量 出 濃度 了 ，怎麼辦 ？ then|measure|out|concentration|past tense marker|what to do Then, after measuring the concentration, what should we do?

大家 看 一下 這個 醫學 臨床 的 一個 數據 everyone|look|briefly|this|medical|clinical|possessive particle|a|data Everyone, take a look at this clinical medical data.

我 如果 把 這 兩個 Aβ 的 42 跟 40 I|if|(particle indicating disposal)|this|two|Aβ|(possessive particle)|and If I take these two Aβ, 42 and 40,

把 它 做 一個 比值 to make|it|do|a|ratio and create a ratio of them.

你 就 可以 區別 出 健康 跟 不 健康 的 群組 you|then|can|distinguish|out|healthy|and|not|healthy|possessive particle|groups You can distinguish between healthy and unhealthy groups.

那 群組 精確度 到 85% ，但 還 不夠 that|group|accuracy|reached|but|still|not enough The accuracy of that group is 85%, but it's still not enough.

因為 我 目標 要 去 診斷 出 MCI because|I|goal|want|to|diagnose|out|MCI Because my goal is to diagnose MCI.

如果 MCI 沒有 辦法 診斷 ，也 是 枉然 if|MCI|has no|method|diagnosis|also|is|in vain If MCI cannot be diagnosed, it is also in vain.

所以 我們 針對 這個 我們 其實 不要 再 做 檢驗 了 so|we|regarding|this|we|actually|should not|again|do|testing|past tense marker So we actually don't need to do the tests for this anymore.

它 只要 檢 一次 就 好 了 it|only needs|check|once|then|| It only needs to be tested once.

我們 就 把 它 做 不同 的 演算法 we|then|(particle indicating action)|it|use|different|(possessive particle)|algorithm We will apply different algorithms to it.

這 不同 的 演算法 ，你 就 可以 發現 this|different|possessive particle|algorithm|you|then|can|discover With these different algorithms, you will be able to discover.

我 用 Aβ 跟 Tau 蛋白 的 濃度 I|use|Aβ|and|Tau|protein|possessive particle|concentration I use the concentrations of Aβ and Tau proteins.

你 就 可以 看到 ，我們 很 容易 把 MCI 跟 那個 阿茲海默症 分開 you|then|can|see|we|very|easily|separate|MCI|with|that|Alzheimer's disease|distinguish You can see that we can easily distinguish MCI from Alzheimer's disease.

早期 的 都 可以 分開 early|possessive particle|all|can|separate Early cases can also be separated.

那 在 這個 時候 ，它 準確度 到 80% at that|in|this|moment|it|accuracy|reached At this point, its accuracy is 80%.

其實 我們 的 數據 是 85% actually|we|possessive particle|data|is Actually, our data is 85%.

只是 用 大於 80% 比較 安全 一點 just|using|greater than|relatively|safe|a little bit It's just a bit safer to use greater than 80%.

所以 到 目前 為止 我們 實行 了 兩個 任務 so|until|present|up to|we|have implemented|past tense marker|two|tasks So far, we have carried out two tasks.

完成 了 兩個 任務 complete|past tense marker|two|tasks We have completed two tasks.

這 兩個 任務 完 了 以後 this|two|tasks|finished|past tense marker|after After these two tasks are completed

我們 可以 宣稱 ： 我們 研究 團隊 已經 成功 地 開發 了 世界 上 唯一 …… we can declare: our research team has successfully developed the only one in the world...

這 研究 團隊 包括 廠商 因為 你 沒有 弄出去 就 沒有 應用 嘛 this|research|team|includes|manufacturer|because|you|did not|get it out|then|did not|application|particle indicating obviousness This research team includes manufacturers because if you don't get it out, there won't be any application.

大家 也 享受 不到 那個 好處 啊 everyone|also|enjoy|unable to enjoy|that|benefit|ah Everyone won't be able to enjoy that benefit.

所以 我們 研究 團隊 已經 成功 開發 出 so|our|research|team|already|successfully|developed|out So our research team has successfully developed

世界 上 唯一 能夠 用 抽血 來 鑑定 MCI 的 方法 world|on|only|able to|use|blood draw|to|diagnose|MCI|possessive particle|method the world's only method that can diagnose MCI through blood tests.

這個 在 全世界 其實 掀起 很大 的 一個 浪濤 this|in|the whole world|actually|stirred up|very big|a|one|wave This has actually caused a huge wave around the world.

所以 每 一次 減量 呢 so|every|time|reduction|question particle So every time we reduce the amount,

它 的 特性 是 抽血 檢驗 ，非常 重要 it|possessive particle|characteristic|is|blood draw|test|very|important Its characteristic is blood testing, which is very important.

因為 抽血 檢驗 非常 重要 因為 可以 放在 健檢裡 because|blood draw|test|very|important|because|can|be included in|health checkup Because blood testing is very important as it can be included in health check-ups.

然後 抽 一點 血 我們 就 可以 知道 了 then|draw|a little|blood|we|then|can|know|past tense marker Then, by drawing a little blood, we can know.

然後 單一 步驟 then|single|step Then a single step.

然後 干擾 度 非常 低 因為 我們 用 的 是 磁珠 then|interference|level|very|low|because|we|use|possessive particle|is|magnetic beads Then the interference level is very low because we use magnetic beads.

磁性 的 東西 拿來 做 免疫檢測 magnetic|possessive particle|thing|brought|do|immunoassay Magnetic materials are used for immunoassays.

是 它 對 很多 其他 雜質 的 干擾 性 非常 少 is|it|to|many|other|impurities|possessive particle|interference|nature|very|little It has very little interference from many other impurities.

這 跟 光學 的 檢驗 不太 一樣 this|with|optical|possessive particle|inspection|not very|the same This is quite different from optical testing.

我 是 光電 的 I|am|optoelectronics|possessive particle I am in optoelectronics.

他 剛剛 介紹 我 是 光電 專家 He|just|introduced|I|am|optoelectronics|expert He just introduced me as an optoelectronics expert.

（笑聲 ） laughter (Laughter)

我 是 光電 的 ，但是 你 不用 磁 不行 I|am|optoelectronics|possessive particle|but|you|don't need|magnet|not okay I am in optoelectronics, but you can't do without magnets.

因為 光電 在 檢驗 上 它 的 靈敏度 會 受到 干擾 很大 Because the sensitivity of photoelectric testing can be greatly interfered with.

但 磁 的 干擾 度 非常 低 ，這是 特性 but|magnetic|possessive particle|interference|degree|very|low|this is|characteristic However, the degree of magnetic interference is very low, which is a characteristic.

還有 它 的 靈敏度 很 高 ，它 可 以 來 操作 簡單 可 適用於 健康檢查 also|it|possessive particle|sensitivity|very|high|it|can|be|used for|operation|simple|can|be applied to|health check Also, its sensitivity is very high, making it easy to operate and suitable for health checks.

全民 健檢 其實 是 非常 好 的 Universal health checks are actually very good.

不過 這裡 我 要 特別 聲明 一下 however|here|I|want|especially|clarify|a little However, I want to make a special statement here.

因為 我 怕 去 觸犯 到 衛福部 的 法律 because|I|afraid|to|violate|to|Ministry of Health and Welfare|possessive particle|law Because I am afraid of violating the laws of the Ministry of Health and Welfare.

我們 這個 只能 做 健檢 之用 ，目前 we|this|can only|do|health checkup|for use|currently We can only use this for health checks, currently.

因為 還 沒有 通過 FDA 、 TFDA 還在 進行 當中 because|still|not|approved|FDA|TFDA|still|ongoing|in progress Because it has not yet passed FDA, TFDA is still in progress.

所以 目前 只能 做 健檢 so|currently|can only|do|health checkup So for now, I can only do health checks.

已經 可以 做 健檢 在 台灣 已經 可以 做 健檢 了 Health checks can already be done in Taiwan.

但是 不 能夠 那個 but|not|able to|that But I can't do that.

我 這樣的話 就 很 安全 了 因為 他們 不會 找 我 了 I|in that case|then|very|safe|past tense marker|because|they|will not|find|me|past tense marker In this case, I will be very safe because they won't look for me.

（笑聲 ） laughter (Laughter)

好 ，最後 ，我要 做 結論 了 okay|finally|I want to|make|conclusion|past tense marker Okay, finally, I want to make a conclusion.

我們 早期 檢驗 是 杜絕 阿茲海默症 的 不二法門 we|early|testing|is|eliminating|Alzheimer's disease|possessive particle|only way Our early examination is the only way to eliminate Alzheimer's disease.

所以 大家 聽 了 我 今天 演講 so|everyone|listened|past tense marker|I|today|speech So everyone, after listening to my speech today.

其實 ，只要 有 疑問 ，就 趕快 去 做 健檢 actually|as long as|have|questions|then|quickly|go|do|health checkup In fact, as long as you have doubts, you should quickly go for a health check.

花 一點 小錢 當然 現在 比較 貴 一點 了 spend|a little|money|of course|now|relatively|expensive|a little|past tense marker Spending a little money is of course a bit more expensive now.

但是 等到 全民 健檢量 大 的 時候 自然 會 低 下來 but|when|whole population|health check-up rate|high|possessive particle|time|naturally|will|lower|down But when the volume of national health checks increases, the cost will naturally go down.

所以 這 不用 擔心 so|this|doesn't need to|worry So there's no need to worry about this.

所以 早期 檢驗 是 杜絕 阿茲海默症 危害 的 不二法門 so|early|testing|is|eliminating|Alzheimer's disease|harm|possessive particle|only way So early testing is the only way to eliminate the harm of Alzheimer's disease.

磁 減量 免疫檢測 方法 也 就是 我們 的 IMR magnetic|reduction|immunoassay|method|also|is|our|possessive particle|IMR The magnetic reduction immunoassay method is our IMR.

堪稱 是 阿茲海默症 的 防火牆 can be called|is|Alzheimer's disease|possessive particle|firewall It can be called the firewall against Alzheimer's disease.

所以 有 這 一個 好消息 so|there is|this|one|good news So there is this good news.

我 想 對於 我們 全民 健康 是 一個 正面 的 I|want|regarding|us|whole population|health|is|a|positive|particle I want to say that our national health is a positive thing.

那 我 要 搖旗吶喊 ，搖鈴 ，搖鈴吶喊 then|I|want|wave the flag and shout|ring the bell|ring the bell and shout So I want to wave the flag, ring the bell, and shout.

呼籲 政府 為了 全民 的 健康 跟 節省 社會 資源 call on|government|for|all people|possessive particle|health|and|saving|social|resources I urge the government to prioritize the health of all citizens and save social resources.

不要 只 改長 照長 照 do not|only|change length|according to length|according to Do not just focus on long-term care.

我 不 知道 政府 有 多少 錢 可以 長照 I|not|know|government|has|how much|money|can|long-term care I don't know how much money the government has for long-term care.

不過 ，在 推動 長 照 政策 時 however|when|promoting|long-term|care|policy|time However, when promoting long-term care policies,

我 希望 政府 能夠 正視 阿茲海默症 的 健檢 的 必要性 I|hope|government|can|take seriously|Alzheimer's disease|possessive particle|health checkup|possessive particle|necessity I hope the government can recognize the necessity of health checks for Alzheimer's disease.

因為 據我所知 because|as far as I know Because, as far as I know,

失智症 目前 所 需要 花掉 政府 長照 的 錢 是 相當 龐大 的 dementia|currently|all|needs|spent|government|long-term care|possessive particle|money|is|quite|large|possessive particle The amount of money that the government currently needs to spend on long-term care for dementia is quite substantial.

所以 如果 能夠 防火牆 都 把 它 擋住 的話 so|if|can|firewall|all|(particle indicating action)|it|block|(conditional particle) So if we can block it all with a firewall,

就是 可以 減少 相當 大 一部分 的 社會 資源 that is|can|reduce|quite|large|a portion|possessive particle|social|resources we can significantly reduce a large portion of social resources.

所以 我 在 最後 祝福 大家 so|I|at|last|bless|everyone So in the end, I wish everyone well.

活 得 老 、 活 得 健康 、 活 得 有 尊嚴 Live long, live healthily, live with dignity.

然後 ，謝謝 各位 的 聆聽 ！ then|thank you|everyone|possessive particle|listening Then, thank you all for listening!

（掌聲 ） applause (Applause)